At the heart of precision medicine

The emergence of artificial intelligence (AI), applied to the field of health has seen medicine develop towards 4P medicine: Preventive, Predictive, Participatory and Personalised

This new approach emerged as the result of a simple observation: the same drug, at the same dosage, does not suit everyone.

Taking into account individual genetic variability, the environment and the lifestyle of each individual, personalised medicine offers tremendous prospects for improving the therapeutic journey of a patient.

The use of artificial intelligence (AI) in the field of health now provides values capable of giving information on the efficacy of a treatment, depending of the individual and their biological characteristics.

This revolution has been made possible thanks to:

  • the development of algorithms capable of processing, sorting, assembling and analysing large volumes of data
  • powerful computers cable of carrying out massive calculations
  • biological and multi-genomic knowledge
  • the high technicity of drugs

By combining the technologies of information, knowledge, transcriptomics and the high-level biotherapies, mYXpression rheumatoid provides each patient, treated or about to be treated with a biotherapy, with a test to come up with a biotherapy that is suited to that person’s biology.

Thanks to a more precisely targeted treatment, the medical care and the quality of life of a patient are significantly improved, and hospitalisation costs and biomedical expenditure can be considerably reduced.

Methodology of the technology

The mYXpression rheumatoid test is based on three major areas of expertise:

  • Mastery of the latest RNA transcriptome sequencing technologies (individual multi-genome signature).
  • Massive use of new information technologies and of Big Data bringing together international clinical studies (digital database).
  • The development of massive calculations and automatic learning algorithms (machine learning) to generate powerful and robust tools to make a customised decision to help the patient throughout their therapeutic journey.

Thanks to Big Data technologies, mYXpression rheumatoid has collected a large amount of genomic data. All this data comes from international clinical studies made public by prestigious universities such as Berkeley, Cambridge and highly specialised sites.

From this unique savoir-faire was born a unique information database

After identifying the most relevant studies on rheumatoid arthritis, the raw data contained was extracted and then stored to be turned into high added-value information using artificial intelligence developed by mYXpression.

This unique know-how gave rise to a unique database, comprising elements on immune deregulation specific to rheumatoid arthritis, to which is added information specific to each of the existing biotherapies.

Via the mYXpression rheumatoid test, the personal transcriptome signature is compared with all this information, then analysed, calculated in our data centre, to produce a personal efficacy score for various biotherapies.

Transcriptome expertise & data protection

The transcriptome platform that sequences the blood samples has 20 years’ experience in the field of genomics. It has the latest generation equipment and is run by technical team at the cutting-edge of knowledge.

The analyses are conducted strictly complying with current confidentiality and quality standards to produce a unique transcriptome signature for the patient.

The analysis called "RNAseq" or gene expression study quantifies inflammation biomarkers related to rheumatoid arthritis.

Once this analysis has been carried out, our dedicated algorithm does billions of calculations to come up with their level of efficacy, one biotherapy at a time.

  • The blood sample from the patient is recorded electronically upon receipt at the laboratory.
  • The messenger RNA of the sample is extracted
  • A quality control of the messenger RNA of the sample is carried out
  • High-speed RNA sequencing called "RNAseq" is carried out
  • Massive calculations using our dedicated algorithm are made
  • The most effective biotherapy is targeted, and inefficient biotherapies are excluded
  • The personal RITI® report is drawn up for the patient
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